Antifungal Activity of a Polyacetylene against the Fungal Pathogen of Japanese Oak from the Liquid Culture of the Edible Mushroom, Hypsizygus marmoreus

Three polyacetylene compounds, 1, 2 and 3, have been isolated from the organic extract of a liquid culture of Hypsizygus marmoreus (Peck.) Bigelow (Japanese name: Bunashimeji). The structures of 1, 2 and 3 were determined by using spectroscopic methods. Compound 3 is new, and was identified as 8(E)-decene-4,6-diyn-1,2,10-triol. Compound 1 exhibits antifungal activity against the pathogenic fungus Raffaelea quercivora responsible for Japanese oak wilt.